A “hyperactive/impulsive motor phenotype” (consisting of clusters of very intense spontaneous activity) has been described recently in a zebrafish model established to investigate the effect of knocking down a homolog of Latrophilin 3 (Lphn3.1; one of the zebrafish orthologs of LPHN3, a susceptibility gene for ADHD [63]) during development [56]. The gene discussed is ADGRL3; the disease is attention deficit-hyperactivity disorder.