For example, Karlsson et al. [42] recently showed that carrying a HOXB13 G84E mutation [24], which occurs at a frequency of ∼1.3% in Sweden, is most strongly associated with hereditary (OR = 6.6) and early-onset (OR = 8.6) PCa and that the risk for G84E mutation carriers of developing disease is increased significantly for those carrying a higher burden of established common GWA study variants. Here, HOXB13 is linked to posterior cortical atrophy.