Our findings also suggest that subjects with poor HbA1c and fasting glucose control would experience the maximum benefit of vitamin E on reducing HbA1c and fasting insulin concentrations, perhaps by controlling excess oxidative stress secondary to hyperglycaemia, inhibiting the glycosylation of haemoglobin, and / or protecting beta cells function in those patients with poor glycaemic control. Here, INS is linked to Hyperglycemia.