As Kunihiko Watanabe reported that immunoreactivity for the EGFR prevailed in primary glioblastomas but was rare in secondary glioblastomas [39], it infers that disturbance of EGF-EGFR signalling pathway including SNP in EGF and EGFR genes may generally participate in primary glioblastomas instead of the secondary glioblastomas. Here, EGF is linked to glioblastoma.