Overall, significant associations between the EGF +61G/A polymorphism and glioma risk were observed in all genetic models (a versus A, OR = 1.22, 95% CI = 1.11–1.33; aa/Aa versus AA, OR = 1.21, 95% CI = 1.06–1.38) (Fig. 2 and Fig. S1). Here, EGF is linked to central nervous system cancer.