Owing to the consistency of statistical results obtained from analyses of lung SCC and paired normal tissues (Paired T-test N, average ratio, Mascot Score, multipoint repetitive identification, protein functions, and bioinformatics analysis), we successfully identified several proteins that were definitely involved in cancer, including YWHAZ, TPI1, ROCK1, CAT, ENO1, VCR, VIM, GSTP, and ANXA2. Here, ANXA2 is linked to cancer.