Knocking down MCT4 in breast cancer cells and MCT1 in intestinal epithelial cells both led to the reduction in the expression of fully glycosylated CD147 and the accumulation of core-glycosylated CD147 in the ER, implicating that MCTs (MCT1, MCT4) regulate the maturation and trafficking of CD147 [58,59]. This evidence concerns the gene BSG and breast carcinoma.