Nearly all the results obtained in vivo, whether they concerned subcutaneous tumor cell injections (tumor volume, mitotic index or Ki67 percentage) or intraperitoneal xenografts (mean weight of mice, median carcinosis score of the diaphragm, liver and intestine, mitotic index or Ki67 percentage), we observed no proliferation increase associated with the HA-CMC barrier. Here, MKI67 is linked to neoplasm.