In another study, rats treated with a TNF-α blocker (rhTNFRFc) showed some amelioration in pulmonary hemodynamics, right ventricular hypertrophy and pulmonary inflammation[65] and in pigs with endotoxemic-shock-induced pulmonary hypertension, Etanercept was able to lower both pulmonary arterial pressure and pulmonary vascular resistance compared to pigs without Etanercept therapy[66]. Here, TNF is linked to pulmonary arterial hypertension.