Since these changes could not be correlated with adequate changes of the corresponding mRNA levels, a finding also confirmed by the MCT model of experimental pulmonary hypertension[42], Brock et al. identified a posttranscriptional mechanism to be responsible for the downregulation of BMPR2, involving IL-6, the signal transducer and activator of transcription STAT3 and the microRNA cluster 17/92[43]. This evidence concerns the gene IL6 and pulmonary hypertension.