In this context, our attention has been focused on the study of the correlation between caveolae/lipid rafts and redox signaling in the human erythromegakaryocytic cell line, B1647, a model of acute myeloid leukemia (AML) constitutively producing VEGF and expressing its tyrosine-kinase receptor VEGFR-2 [19]. The gene discussed is VEGFA; the disease is acute myeloid leukemia.