NOX4 and leukemia: We previously reported that, in B1647 cells expressing Nox2 and Nox4, VEGF signaling and Nox activity are coupled [20, 21]; moreover, it has been recently demonstrated that inhibitors of both Nox and VEGF receptors are able to induce apoptosis in leukemia cell lines and that lipid rafts play a role in this process [40].