CCR2 and cystitis: In the next sections, we will present a summary of recent studies from our laboratory that addresses the role(s) of two chemokine/receptor pairs (CXCL12/CXCR4; CCL2/CCR2) and the cytokine/receptor pair (transforming growth factor (TGF-β)/TGF-β type 1 receptor) in urinary bladder inflammation and somatic sensitivity in a CYP rat model of urinary bladder inflammation.