Bevacizumab (Avastin) is an anti-VEGF mAb that is approved for use in several cancers, including metastatic colorectal cancer (mCRC), non-squamous, non-small cell lung cancer (NSCLC), glioblastoma, and metastatic renal cell carcinoma. The gene discussed is VEGFA; the disease is non-small cell lung carcinoma.