In this study, SFI showed a dose-dependent protective effects in rat acute pancreatitis, which may exert an anti-inflammatory effect and reduce the histological damage due to its ability to regulate the production of cytokines, the oxidative stress, and the NF-κB activity and to cause MPO, MDA, and GSH to revert to control levels. This evidence concerns the gene NFKB1 and acute pancreatitis.