In this study, we found that the correlation between MMP-9 and ITGA-3 genes with epithelial marker EGFR has been strong, whereas no relationship between the tumor expression of MMP-2, FN-1, and ITGB-5 with non-ECM molecules VEGF, KI-67, P53, and Bcl-2 could be demonstrated. The gene discussed is ITGB5; the disease is neoplasm.