In 1999, Haler et al. studied the expression levels of integrins alpha 2, 3, 5, and 6 using IHC in lineages of liver metastatic colorectal carcinoma cells; an increased expression of integrins alpha 2 and alpha 3 was observed, particularly, with regard to the potential dissemination of CRC [31]. This evidence concerns the gene ITGA2 and colorectal carcinoma.