This study aimed to evaluate the relationship of the expression levels of select ECM genes and proteins, FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9, with CRC progression and dissemination and with that of P53, Bcl-2, KI-67, EGFR, and VEGF, as it has been shown by several authors that proliferation, apoptosis, and cell migration are regulated by cell-cell interaction and extracellular matrix cell components. This evidence concerns the gene ITGA3 and colorectal carcinoma.