It is possible that the increased expression of integrins alpha v beta 3 and alpha v beta 5 promotes the linking of tumor cells in the temporary matrix proteins such as vitronectin, fibrinogen, von Willebrand factor, osteopontin, and fibronectin that are deposited in the tumor microenvironment, facilitating the process of endothelial angiogenesis [34]. Here, SPP1 is linked to neoplasm.