In the present study, while evaluating gene expression, there was a significant difference in the expression of integrin alpha 3, a result validated by the analysis of protein expression by the immunohistochemical method, and a greater expression was observed in the TNM III and IV groups than in the TNM I and II groups, thus suggesting a possible relation of integrin 3 with more advanced stages of colorectal cancer. Here, ITGA3 is linked to colorectal cancer.