DRD2 and neuroblastoma: After transfecting the different CADPS2 cDNA clones in frame with a C-terminal V5 tag into the SHSY5Y cell line, derived from neuroblastoma and expressing dopaminergic markers (Sabens & Mieyal, 2010), co-immunoprecipitation assays of the corresponding cell lysates with an anti-D2DR antibody and Western blot analysis against the V5 tag showed that the novel missense change p. Asp1113Asn decreased the protein–protein interaction between CADPS2 and D2DR (Fig 1).