After transfecting the different CADPS2 cDNA clones in frame with a C-terminal V5 tag into the SHSY5Y cell line, derived from neuroblastoma and expressing dopaminergic markers (Sabens & Mieyal, 2010), co-immunoprecipitation assays of the corresponding cell lysates with an anti-D2DR antibody and Western blot analysis against the V5 tag showed that the novel missense change p. Asp1113Asn decreased the protein–protein interaction between CADPS2 and D2DR (Fig 1). This evidence concerns the gene CADPS2 and neuroblastoma.