ALKBH1 and amyloidosis: Although not classified as a hub in the MCS maps, the entorhinal cortex is known to be affected early in AD pathogenesis and it has been shown to demonstrate AD-related alterations in metabolic correlations.1 There is an evident amyloid-related decrease in interhemispheric metabolic correlations between homologous regions in the AβH group relative to the AβL group in all seed regions.