Regardless of APOE ε4 genotype status, the cognitive decline at early stages of AD has recently been linked to the β-amyloid deposition in several regions, including the paracentral lobule.36 Our results also suggest the metabolic connectivity of the paracentral lobule is modulated by β-amyloid irrespective of the APOE ε4 genotype. This evidence concerns the gene APOE and Mental deterioration.