To summary, in this meta-analysis we found that Gln939Gln genotype was associated with significantly increased risk of lung cancer in Asian population but not in Caucasians; the PAT −/− genotype significantly reduced susceptibility to lung cancer in Caucasian population but not in Asians; the XPC Ala499Val polymorphism was not associated with lung cancer risk. The gene discussed is XPC; the disease is lung cancer.