PRODH maps to the 22q11.2 region deleted in velocardiofacial syndrome (VCFS), a haploinsufficiency disorder that leads to a variety of physical and psychiatric problems, including SZ and ASD, and IFITM1 has been found to be differentially expressed in the brains of patients with SZ and ASD [133]–[141]. The gene discussed is PRODH; the disease is 22q11.2 deletion syndrome.