On the other hand, many studies showed that low adiponectin concentrations correlated with high plasma insulin and high IR, while adiponectin administration was found to suppress proinflammatory agents, e.g., TNF-α and IL-6, and to directly ameliorate endothelial dysfunction by increasing nitric oxide (NO) production [11,12,13,14]. The gene discussed is ADIPOQ; the disease is endothelial dysfunction.