It was recently shown that the specific reorganization of immune system during the spontaneous development of a profound SLE-like pathology in MRL-lpr/lpr mice is associated with changes in the differentiation profile and the level of proliferation of bone marrow hematopoietic stem cells and with the production of DNase, ATPase, and amylase abzymes [35], [36]. This evidence concerns the gene DNAH8 and systemic lupus erythematosus.