As shown in Table 4 and Figure S1, 10 genetic variants in 8 genes are significantly associated with T2DM in the meta-analysis, including rs4402960 and rs1470579 in IGF2BP2, rs10946398 in CDKAL1, rs864745 in JAZF1, rs13266634 in SCL30A8, rs1111875 and rs7923837 in HHEX, rs7903146 in TCF7L2, rs1113132 in EXT2, and rs8050136 in FTO gene. The gene discussed is HHEX; the disease is type 2 diabetes mellitus.