Among all SNPs, six SNPs in five genes were nominally associated with T2DM, including rs4402960 in IGFBP2 (OR, 1.13; 95% CI, 1.033–1.257, P = 0.013), rs1470579 in IGFBP2 (OR, 1.1; 95%CI, 1.006–1.220, P = 0.049), rs10946398 in CDKAL1 (OR, 1.14; 1; 95% CI, 050–1.249; P = 0.005), rs13266634 in SLC30A8 (OR, 1.22; 95% CI, 1.127–1.334; P<0.0001), rs1111875 in HHEX (OR, 1.19; 95% CI, 1.088–1.303; P<0.0001), and rs1153188 in DCD (OR, 1.55; 95% CI, 1.107–2.18, P = 0.02) genes. The gene discussed is IGFBP2; the disease is type 2 diabetes mellitus.