However, this study are still insufficiently powered to validate the association of variants in ADAM30, NOTCH2, THADA, ADAMTS9, WFS1, VEGFA, LOC387761, and TSPAN8/LGR5 genes with T2DM, probably owing to their low allele frequencies and small effects in Han Chinese. The gene discussed is ADAM30; the disease is type 2 diabetes mellitus.