This directly implicates TrkAIII in the regulation of SOX2, Nestin and Nanog involvement in NB cancer stem cell biology [74], is consistent with reports that cancer stem cells express higher levels of SOD2 [29], [45], [46] and is, therefore, of relevance to regulation of the cancer stem cell niche in high TrkA expressing unfavourable NBs. This evidence concerns the gene SOX2 and cancer.