This implicates IP3K and NF-κB but not MAPKs in TrkAIII stimulation of SOD2 expression, supports previous observations that spontaneously active TrkAIII signals through IP3K/Akt/NF-κB but not Ras/MAPK [1] and that SOD2 expression is induced by NF-κB in NB and other cell lines [25], [71] but differs to reports that SOD2 expression is stimulated by the TrkA ligand NGF through rac7, Ki-Ras and CREB transcription factor [14], [15], [47]. This evidence concerns the gene CREB1 and neuroblastoma.