Since, spheroidal growth under defined conditions is a characteristic of neural cancer stem cells [66]; cancer stem cells express higher levels of SOD2 than non-stem cell counterparts [45], [46]; TrkAIII promotes a more stem cell-like phenotype [1], [4]; and NB staminality associates with increased CD133, CD117, SOX2, Nestin and Nanog expression [66], [68], [69], spheroid growth capacity and the expression of SOD2, CD133, CD117, SOX2, Nestin and Nanog were compared in pcDNA control, TrkA and TrkAIII SH-SY5Y cells. The gene discussed is SOX2; the disease is cancer.