The present study was conducted to investigate the prevalence of SOX2, PIK3CA, FGFR1 and BRF2 gene copy number changes in a large, unselected cohort of surgically resected NSCLC patients, to verify concurrent genomic gains, and to determine whether copy number alterations in these genes affect patient outcome. This evidence concerns the gene FGFR1 and non-small cell lung carcinoma.