Despite data from a recent meta-analysis suggesting a favorable prognostic impact for SOX2 expression in NSCLC regardless of histology,[23] most studies showed that SOX2 protein overexpression predicted prolonged survival in surgically resected lung SCC [7]–[8], while its survival impact in lung adenocarcinoma remains controversial [21], [24]. Here, SOX2 is linked to lung adenocarcinoma.