TLR3 and toxic epidermal necrolysis: As TLR3 recognizes double-stranded RNA these data support an inductive role for PHCEC in response to infection or possibly TLR3 related immune-mediated disease e.g. SJS-TEN, dry eye disease states, may induce an increase in CXCL10 and a reduction in NK cells exacerbating infection or persistence of inflammation.