In order to examine the impact of DOX-NPs (low dose), alone and in combination with MPL-pSi, on the population of tumor-infiltrating immune cells, we examined CD8+ cytotoxic T lymphocytes (CTL), F4/80+ and CD204+ myeloid cells, and 33D1+ DC in the tumors of control and particle-treated animals. The gene discussed is CD8A; the disease is neoplasm.