We and others have reported that upon infection of the macrophage, multiple signaling proteins such as IRAK-1, JAK2 and MAP Kinases, transcription factors STAT-1, AP-1 and NF-κB, and also the translational protein mammalian/mechanistic target of rapamycin (mTOR) are altered [5]–[8]. The gene discussed is NFKB1; the disease is infection.