Reductions in GAD65 and GAD67 have been shown in the brains of autistic patients [33] and in association with bipolar disorder and depression [34].While manipulating GABAergic transmission systemically is well-known to strongly modulate anxiety-like behaviors [36]–[39] and amygdala reactivity [40], [41], targeting GABAergic transmission directly in the rat amygdala was found to affect anxiety-like behaviors [42], social interactions [43] and responses in the sympathetic nervous system [44]. This evidence concerns the gene GAD1 and Anxiety.