Based on the observation that several vaccination regimens and pathogen infections have been shown to transiently increase viral RNA in plasma of HIV-1-infected patients in ART, recently, the use of Toll-like receptors (TLRs) agonist has been suggested to both reactivate HIV-1 from latently infected cells and to boost HIV-specific cytotoxic CD8+ T cell immunity [200,264]. Here, CD8A is linked to infection.