IGHE and allergic disease: Therapeutic anti-IgE antibodies, omalizumab, able to reduce free IgE levels avoiding the binding of IgE to Fcε RI and the following development of allergic reaction (crosslinking IgE and triggering degranulation and syntesis of new-generated chemical mediators of IgE-sensitized cells) are now widely used in the therapy of allergic bronchial asthma [15-34].