IGHE and cystic fibrosis: The cutoff for total serum IgE has not been rigorously addressed in asthma, although in CF in the UK a cutoff of >180 IU/mL was 91% sensitive and 90% specific [18] in contrast to an Indian cohort of asthmatic patients with ABPA in whom a total serum IgE of 2346 IU/mL (sensitivity 87.5%, specificity 66.9%) appeared optimal [5].