Since APOE e4 is a risk factor for both cognitive decline before the age of 60 years (Caselli et al., 2009) and dementia (Corder et al., 1993) and is hypothesized to modify cortisol's association with cognitive function (Lee et al., 2008), we also conducted analyses stratified by APOE ε4 status. This evidence concerns the gene APOE and Mental deterioration.