In this study, we used a human-relevant HBV-HCC mouse model developed by Zheng et al. [28] to examine the efficacy of delivering an MC-liposome vector containing a 3.2 kb androgen receptor (AR; HCC metastasis suppressor) cDNA into Hepatitis B Virus- (HBV-) induced HCC mouse livers and tested whether an MC-carrying AR DNA vector results in expression latency in tumors. The gene discussed is AR; the disease is hepatocellular carcinoma.