CXCL14 and neoplasm: Some CAF-derived factors such as the chemokine CXCL14 exert autocrine effects on fibroblasts (66), while other CAF-derived factors act in a paracrine manner stimulating cancer and stromal cells (e.g., endothelial cells, immune cells), and are involved in the recruitment of host cells into the tumor (29, 40, 67).