A selective recruitment of Treg has been observed in tumor tissue of human pancreatic carcinoma due to an increased expression of a broad variety of T-cell transmigration-relevant addressins on tumor endothelium: E-selectin, ICAM-1 and -2, MAdCAM-1 (mucosal vascular addressin cell adhesion molecule-1), VCAM-1, or CD166 (63). The gene discussed is MADCAM1; the disease is neoplasm.