VDR and hypercalcemia disease: However, based on Ray et al. report in some conditions including “vitamin D receptor defects, abnormalities of 1-alphahydroxylase, hypercalcemia, hypophosphatic rickets, renal failure, sarcoidosis and lymphoma” w 1,25-dihydroxy vitamin D testing is the preferred method to measurement of vitamin D levels in the body (27).