The target/reference (BCL-2/GAPDH) mean ratio was 0.58 ± 0.16 for control group and 1.14 ± 0.13 for treatment group.Therefore, this study was undertaken to reveal the effect of the pentoxifylline on BCL-2 gene expression changes in kidney after a period of ischemia or lack of oxygen in rats. The gene discussed is BCL2; the disease is ischemia.