The dramatic response of the tumor microenvironment to VEGF inhibition may be due to the key role VEGF plays in normal cell viability, including ECs, myeloid cells, and possibly other cell types involved in tissue homeostasis (Chung and Ferrara, 2011; Lazarus and Keshet, 2011; Luo et al., 2011; Potente et al., 2011). This evidence concerns the gene VEGFA and neoplasm.