In the tumor milieu, IL-1 induces expression of various metastatic mediators, such as matrix metalloproteinases (MMP), VEGF, IL-8, IL-6, TNFα, and TGFβ (reviewed in Dinarello, 1996; Apte and Voronov, 2002, 2008; Apte et al., 2006b; Lewis et al., 2006; Voronov et al., 2013). The gene discussed is IL1B; the disease is neoplasm.