In other studies, using large, established tumors that are densely infiltrated by “activated” myeloid cells, it was shown that VEGF mainly originates from such myeloid cells and it controls tumor angiogenesis (reviewed in Apte and Voronov, 2008; Murdoch et al., 2008; Coffelt et al., 2010; Ferrara, 2010a; Mantovani and Sica, 2010; Qian and Pollard, 2010; Ruffell et al., 2010; Allavena and Mantovani, 2012; Gabrilovich et al., 2012). Here, VEGFA is linked to neoplasm.