However, in most malignancies, IL-1 is produced not only by tumor cells, but by other cells, such as neutrophils, macrophages, and MDSCs, recruited to the tumor microenvironment (reviewed in Apte and Voronov, 2008; Witz, 2008; Balkwill and Mantovani, 2010; Demaria et al., 2010; Grivennikov et al., 2010; Hanahan and Weinberg, 2011; Voronov et al., 2013). Here, IL1A is linked to neoplasm.