IL-1, as a major hematopoietic and pro-inflammatory cytokine has dramatic effects on the generation of myeloid cells in the BM and on their recruitment to tumor sites, as well as on the in situ phenotype/function of these cells in the tumor microenvironment (reviewed in Apte and Voronov, 2008; Voronov et al., 2013). This evidence concerns the gene IL1A and neoplasm.