Though knockout of the α7 nAChR subunit does not affect gross neurological function (Orr-Urtreger et al., 1997) or performance on the 5CSRTT (Grottick and Higgins, 2000; Howe et al., 2010; Guillem et al., 2011), recent evidence suggests that activating α7 nAChRs may alleviate the cognitive impairments associated with Alzheimer’s disease and schizophrenia (Levin, 2013). Here, CHRNA7 is linked to Cognitive impairment.