The plasma IL-37, IL-18, and IL-18BP levels in 192 patients with CAD according to medication have been summarized and the results showed that the administration of aspirin, β-blocker, angiotensin-converting enzyme inhibitor (ACEI), angiotensin receptor blocker (ARB), calcium channel blocker (CCB), nitrate and statin had no significant effects on the plasma levels of IL-37, IL-18, and IL-18BP (Table 3). This evidence concerns the gene ACE and coronary artery disorder.