Patients with EDd7 were in a significant worse performance status (ECOG 3/4 63% vs. 3%), showed higher LDH levels (1568 U/l vs. 926 U/l), more signs of leukostasis (dyspnea 78% vs. 35%; acute renal failure 67% vs. 2%) and a higher degree of coagulation disturbances (prothrombin time 40% vs. 60%; fibrinogen 73 mg/dl vs. 283 mg/dl) compared to patients that survived >7 days (Table S2). This evidence concerns the gene F2 and acute kidney injury.