FFAR4 and obesity due to melanocortin 4 receptor deficiency: It is likely that reducing the omega-6:omega-3 utilizing EPA and DHA may be a more effective strategy for attenuating obesity and related health complications, as EPA and DHA, in addition to being potent activators of GPR120, have the capability to be directly stored in phospholipids rather than having to compete for enzymes to be synthesized and then incorporated into the cellular membrane.