To clarify whether FISH or qPCR is the more sensitive approach for an adequate detection of selected deletion regions in FFPE tissues, we used six malignant mesothelioma (MM) FFPE samples, since MM have been shown to harbor CDKN2A-deletions in 25–50% of cases [6], [7]. The gene discussed is CDKN2A; the disease is malignant mesothelioma.