NRAS and melanoma: Comparison of this cohort to previously published survival studies measuring nuclear or cytoplasmic β-catenin in molecularly uncharacterized melanoma tumors remains limited and unavoidably indirect, since these earlier studies did not account for the status of BRAF or NRAS. Furthermore, the molecular characterization of the melanomas in this study is limited with regards to the mutational status of other genes implicated in melanoma biology.