There was no evidence of significant association between COX-2 8473T>C polymorphism and CRC risk when all eligible studies were pooled into the meta-analysis (CC vs. TT: OR = 0.948, 95%CI: 0.843–1.066, P = 0.369; TC vs. TT: OR = 1.008, 95%CI: 0.934–1.088, P = 0.841; CC+TC vs. TT: OR = 0.995, 95%CI: 0.926–1.070, P = 0.899, Figure 3; CC vs. TC+TT: OR = 0.941, 95%CI: 0.842–1.051, P = 0.284). Here, PTGS2 is linked to colorectal carcinoma.