PTGS2 and colorectal carcinoma: There was no evidence of significant association between COX-2 -1195A>G polymorphism and CRC risk when all the eligible studies were pooled into the meta-analysis (GG vs. AA: OR = 0.902, 95% CI = 0.717–1.136, P = 0.380; AG vs. AA: OR = 0.945, 95% CI = 0.835–1.069, P = 0.369; GG+AG vs. AA: OR = 0.940, 95%CI = 0.822–1.074, P = 0.361, Figure 1; GG vs. AG+AA: OR = 0.891, 95%CI = 0.786–1.010, P = 0.072).