Besides CCL2/MCP-1, several other chemokines such as CCL5, C-X-C motif chemokine ligand 5 (CXCL5) and CXCL14 are also involved in adipose tissue macrophage infiltration and obesity-induced insulin resistance [46,80,81]. This evidence concerns the gene CXCL5 and obesity due to melanocortin 4 receptor deficiency.