Examination of the brain morphology of adult and juvenile Trib3-deficient mice revealed increased lateral ventricle size compared to mice with wild type Trib3. In humans, lateral ventricle size increases with aging and enlarged ventricles are associated with age-related brain disorders, including Alzheimer's disease [39], however, lateral ventricle volume also displays a relatively large amount of variability in healthy, non-elderly humans [40]. Here, TRIB3 is linked to early-onset autosomal dominant Alzheimer disease.