PSEN1 and amyloidosis: Indeed, in APP.PS1 mice subjected to a specific BFCN lesion, produced by the immunotoxin anti-p75NGFR-saporin, there is a rapid acceleration of amyloid plaque deposition in the hippocampus that can be appreciated within days [60], [61] indicating that normal cholinergic innervation slows down the generation of new plaques.