In this study, to directly examine the importance of plasminogen in stroke onset and recovery, we investigated the differences of behavioral outcome and contralesional axonal remodeling of the CST in young adult Plg-/- and genetically matched Plg+/+ mice subjected to MCAo, and neurite outgrowth in cortical neurons harvested from both Plg+/+ and Plg-/- embryos. Here, PLG is linked to Stroke.