For example, miR-143 and miR-145 affect cytoskeletal dynamics in SMCs, miR-199a2 and miR-214 control myoblast differentiation, and miR-21 promotes fibrosis and epithelial-to-mesenchymal transition (EMT) and is implicated in cancer, while miR-22 is implicated in regulation of SRF itself in a cardiac overload model. This evidence concerns the gene SRF and cancer.