The objectives of this study were multifold: 1) to determine if the KRAS-variant is associated with endometrial cancer risk; 2) to evaluate the association of miRNA expression signatures with clinical features in tumor specimens from RTOG 9708 and 9905; and 3) to determine whether the KRAS-variant is associated with endometrial cancer biology by evaluating both clinical and miRNA expression associations in these same trials. The gene discussed is KRAS; the disease is neoplasm.