To investigate whether the anti-tumor activity of BRAF-I could be enhanced by PDGFRα inhibition, Colo38, Colo38R, M21, M21R and TPF-10-741 cells were treated with vemurafenib in combination with the PDGFRα inhibitor (PDGFRα-I) sunitinib [22], imatinib [23] or crenolanib [24]. The gene discussed is PDGFRA; the disease is neoplasm.